The commercialization of nanotechnology faces formidable challenges stemming from technical intricacies, regulatory uncertainties, and market perceptions. Scaling up from controlled lab environments to mass production poses issues of reproducibility, quality control, and the preservation of nanomaterial properties. Navigating regulatory ambiguity surrounding novel nanomaterials adds complexity, demanding standardized regulations for global markets. Public skepticism about safety and environmental impacts necessitates significant investments in educating stakeholders. Securing funding amid high development costs, market uncertainties, and regulatory risks is a major hurdle for nanotech startups. Strategic pathways include forming partnerships with industry leaders for resources and expertise, leveraging academic research through spin-offs, targeting specific industry niches, and tapping into government support programs.